Research Progress of undifferentiated proliferation of mesenchymal stem cells 间充质干细胞非分化性增殖的研究进展
It is well known that BMP can induce undifferentiated mesenchymal cells into cartilage and bone irreversibly, resulting in new bone formation, but BMP is only an initiator of osteogenesis and can not further promote the proliferation of differentiated osteoblasts, osteocytes and chondrocytes. 但是,BMP仅是骨生成的启动因子,对已分化的成骨细胞、骨细胞及软骨细胞无进一步促进其增殖作用,而骨细胞形成后的进一步生长,增殖是由其它骨生长因子调节的。
Conclusion: The cultured cells are undifferentiated bone mesenchymal stromal cells and can be used as the seed cells during the study of tissue engineering. 结论:培养的细胞是骨髓间质干细胞;在体外培养条件下,早期生长性状稳定,可作为组织工程的种子细胞。
BACKGROUND: Evidence from in vitro study indicates that bone marrow stromal cells and undifferentiated mesenchymal cells can different into chondrocytes. 背景:研究表明体外分离培养的骨髓基质细胞和未分化的间充质细胞可以分化为软骨细胞。
The anterior periosteal undifferentiated mesenchymal cells of human patella were denser than that of the upper tibias. 人体髌前骨膜生发层未分化间充质细胞分布较密集。
The histiocyte-like ce-lls may be transformed into foamy cells, mononucleated or multinucleated tumor giant cells. Undifferentiated mesenchymal cells were rarely seen. 组织细胞样细胞可演变为泡沫细胞和多核、单核的瘤巨细胞,另见少量未分化间叶细胞。
The histological characteristic features showed: mesenchymal chondrosarcoma was alternative composed by two elementary cell components which were undifferentiated mesenchymal cells together with islands of chondrosarcoma, without segmented structure, the demarcations between mesenchymal cells and islands of chondrosarcoma were limpid. 镜下间叶性软骨肉瘤由两种基本细胞成分,即构成未分化间叶细胞与分化较差的肿瘤性软骨岛交替存在,不形成分叶状结构,间叶细胞与软骨岛分界清晰。
They can make undifferentiated mesenchymal cells differentiate into osteoblasts and form bone tissue. 它能够使未分化的间充质细胞定向分化为成骨细胞并具有形成骨组织的能力。
So it could be used as plasma scaffold production proportion. Conclusion: 1. Dental pulp cells is rich, containing a few undifferentiated mesenchymal cells, and is expected to become one option of seed cells for pulp regeneration. 2. 结论:1、牙髓细胞含量丰富,含有少量未分化间充质细胞,有望成为牙髓再生的种子细胞选择之一。